Aim: To evaluate the effect of different anti-diabetic treatment strategy on oxidative stress markers in patients with\ntype 2 diabetes mellitus (T2DM).\nSubject and methods: A total of 93 patients with T2DM treated with metformin (G1 = 25), OHA (G2 = 22), OA and\ninsulin (G3 = 26) and insulin alone (G4 = 20). In all patients, lipid profile and glycemic indices were assessed using\nroutine laboratory tests. MDA and Oxidized LDL were assessed using commercially available ELISA kits. Laboratory\ntests were performed at baseline and at a control visit after 24 weeks of treatment.\nResults: A significant decrease in the levels of MDA with improvement of glycemic control was observed in the\ngroup receiving OHA in combination with insulin therapy. A similar decrease of oxLDL was observed in all diabetic\nsubgroups with borderline significance in those receiving metformin alone. The remaining clinical and biochemical\nparameters were not changed during follow-up in any of the involved groups.\nConclusion: A combination therapy with insulin was more effective in glycemic control and MDA reduction in T2DM.\nWhereas, a significant oxLDLc reduction was observed in T2DM irrespective of categories of antidiabetic treatment or\nglycemic control.
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